Systematic analysis of low-affinity transcription factor binding site clusters in vitro and in vivo establishes their functional relevance

Binding to binding site clusters has yet to be characterized in depth, and the functional relevance of low-affinity clusters remains uncertain. We characterized transcription factor binding to low-affinity clusters in vitro and found that transcription factors can bind concurrently to overlapping si...

Descripción completa

Detalles Bibliográficos
Autores principales: Shahein, Amir, López-Malo, Maria, Istomin, Ivan, Olson, Evan J., Cheng, Shiyu, Maerkl, Sebastian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452512/
https://www.ncbi.nlm.nih.gov/pubmed/36071116
http://dx.doi.org/10.1038/s41467-022-32971-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452512/
https://www.ncbi.nlm.nih.gov/pubmed/36071116
http://dx.doi.org/10.1038/s41467-022-32971-0

Ejemplares similares