Construction of a culture protocol for functional bile canaliculi formation to apply human iPS cell-derived hepatocytes for cholestasis evaluation

Cholestatic toxicity causes the failure of pharmaceutical agents during drug development and, thus, should be identified at an early stage of drug discovery and development. The formation of functional bile canaliculi in human hepatocytes is required for in vitro cholestasis toxicity tests conducted...

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Detalles Bibliográficos
Autores principales: Horiuchi, Shinichiro, Kuroda, Yukie, Oyafuso, Ryota, Komizu, Yuji, Takaki, Takashi, Maeda, Kazuya, Ishida, Seiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452549/
https://www.ncbi.nlm.nih.gov/pubmed/36071090
http://dx.doi.org/10.1038/s41598-022-19469-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452549/
https://www.ncbi.nlm.nih.gov/pubmed/36071090
http://dx.doi.org/10.1038/s41598-022-19469-x

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