PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIP(L) to promote TNFα-mediated cell death

Activation of TNFR1 by TNFα induces the formation of a membrane-associated, intracellular complex termed complex I. Complex I orchestrates a complex pattern of modifications on key regulators of TNF signaling that collectively determines the cell fate by activating pro-survival or executing cell dea...

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Detalles Bibliográficos
Autores principales: Wu, Guowei, Li, Dekang, Liang, Wei, Sun, Weimin, Xie, Xingxing, Tong, Yilun, Shan, Bing, Zhang, Mengmeng, Lu, Xiaojuan, Yuan, Junying, Li, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452587/
https://www.ncbi.nlm.nih.gov/pubmed/36071040
http://dx.doi.org/10.1038/s41419-022-05206-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452587/
https://www.ncbi.nlm.nih.gov/pubmed/36071040
http://dx.doi.org/10.1038/s41419-022-05206-9

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