Cargando…

Uncoupling of Voltage- and Ligand-Induced Activation in HCN2 Channels by Glycine Inserts

Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are tetramers that generate electrical rhythmicity in special brain neurons and cardiomyocytes. The channels are activated by membrane hyperpolarization. The binding of cAMP to the four available cyclic nucleotide-binding domains...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yüksel, Sezin, Bonus, Michele, Schwabe, Tina, Pfleger, Christopher, Zimmer, Thomas, Enke, Uta, Saß, Inga, Gohlke, Holger, Benndorf, Klaus, Kusch, Jana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452628/ https://www.ncbi.nlm.nih.gov/pubmed/36091400 http://dx.doi.org/10.3389/fphys.2022.895324

Ejemplares similares

Functional and structural characterization of interactions between opposite subunits in HCN pacemaker channels
por: Kondapuram, Mahesh, et al.
Publicado: (2022)

Hydrophobic alkyl chains substituted to the 8-position of cyclic nucleotides enhance activation of CNG and HCN channels by an intricate enthalpy - entropy compensation
por: Otte, Maik, et al.
Publicado: (2018)

All four subunits of HCN2 channels contribute to the activation gating in an additive but intricate manner
por: Sunkara, Mallikarjuna Rao, et al.
Publicado: (2018)

Conformational Flip of Nonactivated HCN2 Channel Subunits Evoked by Cyclic Nucleotides
por: Thon, Susanne, et al.
Publicado: (2015)

Probability Fluxes and Transition Paths in a Markovian Model Describing Complex Subunit Cooperativity in HCN2 Channels
por: Benndorf, Klaus, et al.
Publicado: (2012)

Fluorophore‐Labeled Cyclic Nucleotides as Potent Agonists of Cyclic Nucleotide‐Regulated Ion Channels
por: Lelle, Marco, et al.
Publicado: (2020)

Thermodynamic profile of mutual subunit control in a heteromeric receptor
por: Schirmeyer, Jana, et al.
Publicado: (2021)

Activation gating in HCN2 channels
por: Hummert, Sabine, et al.
Publicado: (2018)

Integrated Allosteric Model of Voltage Gating of Hcn Channels
por: Altomare, Claudia, et al.
Publicado: (2001)

Gabapentin Modulates HCN4 Channel Voltage-Dependence
por: Tae, Han-Shen, et al.
Publicado: (2017)

Molecular Regions Controlling the Activity of Cng Channels
por: Möttig, Holger, et al.
Publicado: (2001)

Distinct Populations of HCN Pacemaker Channels Produce Voltage-dependent and Voltage-independent Currents
por: Proenza, Catherine, et al.
Publicado: (2006)

Bipolar switching by HCN voltage sensor underlies hyperpolarization activation
por: Cowgill, John, et al.
Publicado: (2019)

Direct regulation of the voltage sensor of HCN channels by membrane lipid compartmentalization
por: Handlin, Lucas J., et al.
Publicado: (2023)

Kinetic Relationship between the Voltage Sensor and the Activation Gate in spHCN Channels
por: Bruening-Wright, Andrew, et al.
Publicado: (2007)

HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns
por: Pai, Vaibhav P., et al.
Publicado: (2018)

Salts of HCN‐Cyanide Aggregates: [CN(HCN)(2)](−) and [CN(HCN)(3)](−)
por: Bläsing, Kevin, et al.
Publicado: (2020)

α(5)β(1) integrins in hepatocytes act as receptors for bile acids with a (nor)ursodeoxycholane scaffold
por: Bonus, Michele, et al.
Publicado: (2014)

Isoform-specific Inhibition of N-methyl-D-aspartate Receptors by Bile Salts
por: Koch, Angela, et al.
Publicado: (2019)

The HCN Channel Voltage Sensor Undergoes A Large Downward Motion During Hyperpolarization
por: Dai, Gucan, et al.
Publicado: (2019)

Voltage Sensor Movement and cAMP Binding Allosterically Regulate an Inherently Voltage-independent Closed−Open Transition in HCN Channels
por: Chen, Shan, et al.
Publicado: (2007)

Hysteresis in the Voltage Dependence of HCN Channels: Conversion between Two Modes Affects Pacemaker Properties
por: Männikkö, Roope, et al.
Publicado: (2005)

Reversal of HCN Channel Voltage Dependence via Bridging of the S4–S5 Linker and Post-S6
por: Prole, David L., et al.
Publicado: (2006)

Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate
por: Ryu, Sujung, et al.
Publicado: (2012)

Singlet oxygen modification abolishes voltage-dependent inactivation of the sea urchin spHCN channel
por: Idikuda, Vinay, et al.
Publicado: (2018)

Similar voltage-sensor movement in spHCN channels can cause closing, opening, or inactivation
por: Wu, Xiaoan, et al.
Publicado: (2023)

Corrigendum: Deciphering the function of the CNGB1b subunit in olfactory CNG channels
por: Nache, Vasilica, et al.
Publicado: (2018)

Deciphering the function of the CNGB1b subunit in olfactory CNG channels
por: Nache, Vasilica, et al.
Publicado: (2016)

Cation and voltage dependence of lidocaine inhibition of the hyperpolarization-activated cyclic nucleotide-gated HCN1 channel
por: Putrenko, Igor, et al.
Publicado: (2017)

Changes in Local S4 Environment Provide a Voltage-sensing Mechanism for Mammalian Hyperpolarization–activated HCN Channels
por: Bell, Damian C., et al.
Publicado: (2004)

The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels
por: Porro, Alessandro, et al.
Publicado: (2019)

Single‐molecule tracking of perfringolysin O assembly and membrane insertion uncoupling
por: Senior, Michael J. T., et al.
Publicado: (2022)

Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid
por: Maleeva, Galyna, et al.
Publicado: (2017)

CNA web server: rigidity theory-based thermal unfolding simulations of proteins for linking structure, (thermo-)stability, and function
por: Krüger, Dennis M., et al.
Publicado: (2013)

HCN Channels and Heart Rate
por: Scicchitano, Pietro, et al.
Publicado: (2012)

Review: HCN Channels in the Heart
por: Depuydt, Anne-Sophie, et al.
Publicado: (2022)

Towards targeting protein-protein interfaces with small molecules
por: Gohlke, Holger, et al.
Publicado: (2011)

Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain
por: Dini, Leonardo, et al.
Publicado: (2018)

Biological hydrogen cyanide emission globally impacts the physiology of both HCN-emitting and HCN-perceiving Pseudomonas
por: Anand, Abhishek, et al.
Publicado: (2023)

HCN Channels Modulators: The Need for Selectivity
por: Romanelli, Maria Novella, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_roe0ed213pdt007g4ckc8q6fea