N-acetyl-L-cysteine treatment reduces beta-cell oxidative stress and pancreatic stellate cell activity in a high fat diet-induced diabetic mouse model

Obesity plays a major role in type II diabetes (T2DM) progression because it applies metabolic and oxidative stress resulting in dysfunctional beta-cells and activation of intra-islet pancreatic stellate cells (PaSCs) which cause islet fibrosis. Administration of antioxidant N-acetyl-L-cysteine (NAC...

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Detalles Bibliográficos
Autores principales: Schuurman, Meg, Wallace, Madison, Sahi, Gurleen, Barillaro, Malina, Zhang, Siyi, Rahman, Mushfiqur, Sawyez, Cynthia, Borradaile, Nica, Wang, Rennian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452715/
https://www.ncbi.nlm.nih.gov/pubmed/36093092
http://dx.doi.org/10.3389/fendo.2022.938680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452715/
https://www.ncbi.nlm.nih.gov/pubmed/36093092
http://dx.doi.org/10.3389/fendo.2022.938680

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