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Identification of amino acid residues in the MT-loop of MT1-MMP critical for its ability to cleave low-density lipoprotein receptor

Low-density lipoprotein receptor (LDLR) mediates clearance of plasma LDL cholesterol, preventing the development of atherosclerosis. We previously demonstrated that membrane type 1-matrix metalloproteinase (MT1-MMP) cleaves LDLR and exacerbates the development of atherosclerosis. Here, we investigat...

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Detalles Bibliográficos
Autores principales:	Wang, Maggie, Alabi, Adekunle, Gu, Hong-mei, Gill, Govind, Zhang, Ziyang, Jarad, Suha, Xia, Xiao-dan, Shen, Yishi, Wang, Gui-qing, Zhang, Da-wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452735/ https://www.ncbi.nlm.nih.gov/pubmed/36093157 http://dx.doi.org/10.3389/fcvm.2022.917238

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