Glyoxylase-1 combats dicarbonyl stress and right ventricular dysfunction in rodent pulmonary arterial hypertension

BACKGROUND: Heightened glycolytic flux is associated with right ventricular (RV) dysfunction in pulmonary arterial hypertension (PAH). Methylglyoxal, a glycolysis byproduct, is a highly reactive dicarbonyl that has toxic effects via non-enzymatic post-translational modifications (protein glycation)....

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Detalles Bibliográficos
Autores principales: Prisco, Sasha Z., Hartweck, Lynn, Keen, Jennifer L., Vogel, Neal, Kazmirczak, Felipe, Eklund, Megan, Hemnes, Anna R., Brittain, Evan L., Prins, Kurt W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452736/
https://www.ncbi.nlm.nih.gov/pubmed/36093169
http://dx.doi.org/10.3389/fcvm.2022.940932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452736/
https://www.ncbi.nlm.nih.gov/pubmed/36093169
http://dx.doi.org/10.3389/fcvm.2022.940932

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