Cargando…

Glyoxylase-1 combats dicarbonyl stress and right ventricular dysfunction in rodent pulmonary arterial hypertension

BACKGROUND: Heightened glycolytic flux is associated with right ventricular (RV) dysfunction in pulmonary arterial hypertension (PAH). Methylglyoxal, a glycolysis byproduct, is a highly reactive dicarbonyl that has toxic effects via non-enzymatic post-translational modifications (protein glycation)....

Descripción completa

Detalles Bibliográficos
Autores principales:	Prisco, Sasha Z., Hartweck, Lynn, Keen, Jennifer L., Vogel, Neal, Kazmirczak, Felipe, Eklund, Megan, Hemnes, Anna R., Brittain, Evan L., Prins, Kurt W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452736/ https://www.ncbi.nlm.nih.gov/pubmed/36093169 http://dx.doi.org/10.3389/fcvm.2022.940932

Ejemplares similares

Ferroptosis Promotes Pulmonary Hypertension
por: Vogel, Neal T., et al.
Publicado: (2023)

Ingenuity pathway analysis of the human cardiac cell Atlas identifies differences between right and left ventricular cardiomyocytes
por: Prisco, Sasha Z., et al.
Publicado: (2022)

Sex differences in right ventricular function between Groups 1 and 3 pulmonary hypertension
por: Kazmirczak, Felipe, et al.
Publicado: (2023)

The activity of glyoxylase 1 is regulated by glucose-responsive phosphorylation on Tyr136
por: Cortizo, Fabiola Garcia, et al.
Publicado: (2021)

Sex Differences in Right Ventricular Dysfunction: Insights From the Bench to Bedside
por: Keen, Jennifer, et al.
Publicado: (2021)

Diabetes Enters Stage Right: Genetic Association Studies Suggest Diabetes Promotes Pulmonary Hypertension and Right Ventricular Dysfunction
por: Kazmirczak, Felipe, et al.
Publicado: (2023)

Excess Protein O-GlcNAcylation Links Metabolic Derangements to Right Ventricular Dysfunction in Pulmonary Arterial Hypertension
por: Prisco, Sasha Z., et al.
Publicado: (2020)

Jasmonic acid ameliorates alkaline stress by improving growth performance, ascorbate glutathione cycle and glyoxylase system in maize seedlings
por: Mir, Mudaser Ahmad, et al.
Publicado: (2018)

Dicarbonyl Stress and Glyoxalase-1 in Skeletal Muscle: Implications for Insulin Resistance and Type 2 Diabetes
por: Mey, Jacob T., et al.
Publicado: (2018)

With No Lysine Kinase 1 Promotes Metabolic Derangements and RV Dysfunction in Pulmonary Arterial Hypertension
por: Prisco, Sasha Z., et al.
Publicado: (2021)

Treatment Targets for Right Ventricular Dysfunction in Pulmonary Arterial Hypertension
por: Prisco, Sasha Z., et al.
Publicado: (2020)

Intermittent Fasting Enhances Right Ventricular Function in Preclinical Pulmonary Arterial Hypertension
por: Prisco, Sasha Z., et al.
Publicado: (2021)

Dicarbonyl stress in clinical obesity
por: Masania, Jinit, et al.
Publicado: (2016)

Dual Role of Glyoxal in Metal-Free Dicarbonylation Reaction: Synthesis of Symmetrical and Unsymmetrical Dicarbonyl Imidazoheterocycles
por: Nandwana, Nitesh Kumar, et al.
Publicado: (2019)

Hypochloremia Is a Noninvasive Predictor of Mortality in Pulmonary Arterial Hypertension
por: Prins, Kurt W., et al.
Publicado: (2020)

Reduced free-living activity levels in pulmonary arterial hypertension patients
por: Halliday, Stephen J., et al.
Publicado: (2018)

Dicarbonyl Stress and Atherosclerosis: Is It All RAGE?
por: Muniyappa, Ranganath, et al.
Publicado: (2014)

Dicarbonyl Stress in Diabetic Vascular Disease
por: Stratmann, Bernd
Publicado: (2022)

Synthesis and characterization of cationic dicarbonyl Fe(II) PNP pincer complexes
por: Glatz, Mathias, et al.
Publicado: (2016)

Ketone bodies in right ventricular failure: A unique therapeutic opportunity
por: Blake, Madelyn, et al.
Publicado: (2023)

Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics
por: Rabbani, Naila, et al.
Publicado: (2016)

Dicarbonyl Stress at the Crossroads of Healthy and Unhealthy Aging
por: Nigro, Cecilia, et al.
Publicado: (2019)

Dicarbonyl stress and mitochondrial dysfunction in the aged heart
por: Bou-Teen, Diana, et al.
Publicado: (2023)

Dicarbonyl-modified lipoproteins contribute to proteinuric kidney injury
por: Zhong, Jianyong, et al.
Publicado: (2022)

Experimental Rodent Models of Cardiovascular Diseases
por: Jia, Tian, et al.
Publicado: (2020)

Natriuretic peptide receptor C contributes to disproportionate right ventricular hypertrophy in a rodent model of obesity-induced heart failure with preserved ejection fraction with pulmonary hypertension
por: Agrawal, Vineet, et al.
Publicado: (2019)

Transition from parental prostacyclin to selexipag: a case series of five pulmonary arterial hypertension patients
por: Holthaus, Nathan, et al.
Publicado: (2019)

Clinical features do not identify risk of progression from isolated postcapillary pulmonary hypertension to combined pre‐ and postcapillary pulmonary hypertension
por: Babu, Gautam, et al.
Publicado: (2023)

Protein Modification by Dicarbonyl Molecular Species in Neurodegenerative Diseases
por: Williams, Wesley M., et al.
Publicado: (2011)

Associations of dicarbonyl stress with complement activation: the CODAM study
por: Xin, Ying, et al.
Publicado: (2020)

Dicarbonyl stress, protein glycation and the unfolded protein response
por: Rabbani, Naila, et al.
Publicado: (2021)

Enantio- and diastereoselective diarylmethylation of 1,3-dicarbonyl compounds
por: Li, Xin, et al.
Publicado: (2020)

Clearance and Utilization of Dicarbonyl-Modified LDL in Monkeys and Humans
por: Lankin, Vadim Z., et al.
Publicado: (2023)

Right ventricular plasticity and functional imaging
por: Brittain, Evan L., et al.
Publicado: (2012)

Editorial: Role of Molecular Modulators in Combatting Cardiac Injury and Disease: Prevention, Repair and Regeneration
por: de Castro Brás, Lisandra E., et al.
Publicado: (2022)

Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light
por: Prasse, Carsten, et al.
Publicado: (2018)

Deoxygenative α-alkylation and α-arylation of 1,2-dicarbonyls
por: Jin, Shengfei, et al.
Publicado: (2020)

Nutraceutical Prevention of Diabetic Complications—Focus on Dicarbonyl and Oxidative Stress
por: McCarty, Mark F., et al.
Publicado: (2022)

Alloying Iron into Palladium Nanoparticles for an Efficient Catalyst in Acetylene Dicarbonylation
por: Zhang, Yuchen, et al.
Publicado: (2022)

Modulation of 1,2-Dicarbonyl Compounds in Postprandial Responses Mediated by Food Bioactive Components and Mediterranean Diet †
por: Cruz, Nadia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ndaj6mjaorbclum5knt1jmd4sa