Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep

IGF-1 is a critical fetal growth-promoting hormone. Experimental infusion of an IGF-1 analog, human recombinant LR3 IGF-1, into late gestation fetal sheep increased fetal organ growth and skeletal muscle myoblast proliferation. However, LR3 IGF-1 has a low affinity for IGF binding proteins (IGFBP),...

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Detalles Bibliográficos
Autores principales: Stremming, J, White, A, Donthi, A, Batt, DG, Hetrick, B, Chang, EI, Wesolowski, SR, Seefeldt, MB, McCurdy, CE, Rozance, PJ, Brown, LD
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452821/
https://www.ncbi.nlm.nih.gov/pubmed/36091374
http://dx.doi.org/10.3389/fphys.2022.954948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452821/
https://www.ncbi.nlm.nih.gov/pubmed/36091374
http://dx.doi.org/10.3389/fphys.2022.954948

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