Slingshot homolog-1 mediates the secretion of small extracellular vesicles containing misfolded proteins by regulating autophagy cargo receptors and actin dynamics

Increasing evidence indicates that the accumulation misfolded proteins in Alzheimer’s disease (AD) arises from clearance defects in the autophagy-lysosome pathway. Misfolded proteins such as Aβ and tau are secreted in small extracellular vesicles (i.e., exosomes) and are propagated from cell to cell...

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Detalles Bibliográficos
Autores principales: Cazzaro, Sara, Fang, Cenxiao, Khan, Hirah, Witas, Richard, Kee, Teresa R., Woo, Jung-A. A., Kang, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452914/
https://www.ncbi.nlm.nih.gov/pubmed/36092812
http://dx.doi.org/10.3389/fnagi.2022.933979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452914/
https://www.ncbi.nlm.nih.gov/pubmed/36092812
http://dx.doi.org/10.3389/fnagi.2022.933979

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