Cargando…

ADAM33 Silencing Inhibits Vascular Smooth Muscle Cell Migration and Regulates Cytokine Secretion in Airway Vascular Remodeling via the PI3K/AKT/mTOR Pathway

INTRODUCTION: Vascular smooth muscle cells (VSMCs) are highly involved in airway vascular remodeling in asthma. OBJECTIVES: This study aimed to investigate the mechanisms underlying the effects of a disintegrin and metalloproteinase-33 (ADAM33) gene on the migration capacity and inflammatory cytokin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Fang, Hu, Xin, He, Long, Jiao, Kegang, Hao, Yanyan, Wang, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453083/ https://www.ncbi.nlm.nih.gov/pubmed/36091328 http://dx.doi.org/10.1155/2022/8437348

Ejemplares similares

Silencing a disintegrin and metalloproteinase-33 attenuates the proliferation of vascular smooth muscle cells via PI3K/AKT pathway: Implications in the pathogenesis of airway vascular remodeling
por: Yan, Fang, et al.
Publicado: (2021)

Carnosine attenuates vascular smooth muscle cells calcification through mTOR signaling pathway
por: Huang, Yi, et al.
Publicado: (2020)

Akt/mTOR Role in Human Foetoplacental Vascular Insulin Resistance in Diseases of Pregnancy
por: Villalobos-Labra, Roberto, et al.
Publicado: (2017)

The Inhibition of Insulin-stimulated Proliferation of Vascular Smooth Muscle Cells by Rosiglitazone Is Mediated by the Akt-mTOR-P70S6K Pathway
por: Park, Sungha, et al.
Publicado: (2008)

Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life
por: Davies, Elizabeth R., et al.
Publicado: (2016)

Effect of typhaneoside on ventricular remodeling and regulation of PI3K/Akt/mTOR pathway
por: Zhang, X., et al.
Publicado: (2019)

Vascularization in mTOR Mouse Mutants: An Effort Not in Vein
por: Elziny, Soad, et al.
Publicado: (2023)

Methylprednisolone Inhibits Autophagy of Vascular Endothelial Cells in Rat Femoral Head Via PI3K/Akt/mTOR Pathway
por: Jang, Bo‐yong, et al.
Publicado: (2022)

Adiponectin attenuates the premature senescence of vascular smooth muscle cells induced by high glucose through mTOR signaling pathway
por: Cui, Xing‐Jun, et al.
Publicado: (2020)

Metformin alleviates β-glycerophosphate-induced calcification of vascular smooth muscle cells via AMPK/mTOR-activated autophagy
por: Qiu, Xiaobo, et al.
Publicado: (2021)

The roles of METTL3 on autophagy and proliferation of vascular smooth muscle cells are mediated by mTOR rather than by CDK1
por: Luo, Hanshen, et al.
Publicado: (2023)

PI3K/AKT/mTOR Pathway in Angiogenesis
por: Karar, Jayashree, et al.
Publicado: (2011)

Effect of airway acidosis and alkalosis on airway vascular smooth muscle responsiveness to albuterol
por: Cancado, Jose E, et al.
Publicado: (2015)

Interaction Between CD34(+) Fibrocytes and Airway Smooth Muscle Promotes IL-8 Production and Akt/PRAS40/mTOR Signaling in Asthma
por: Lin, Ting-Yu, et al.
Publicado: (2022)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

MicroRNA-26a protects vascular smooth muscle cells against H(2)O(2)-induced injury through activation of the PTEN/AKT/mTOR pathway
por: Peng, Junlu, et al.
Publicado: (2018)

Ursodeoxycholic acid inhibits intimal hyperplasia, vascular smooth muscle cell excessive proliferation, migration via blocking miR-21/PTEN/AKT/mTOR signaling pathway
por: Huang, Rong, et al.
Publicado: (2020)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

ADAM Metallopeptidase Domain 33 (ADAM33): A Promising Target for Asthma
por: Tripathi, Priya, et al.
Publicado: (2014)

Effect of lithium on ventricular remodelling in infarcted rats via the Akt/mTOR signalling pathways
por: Lee, Tsung-Ming, et al.
Publicado: (2017)

The Mechanism of Aerobic Exercise Regulating the PI3K/Akt-mTOR Signaling Pathway Intervenes in Hippocampal Neuronal Apoptosis in Vascular Dementia Rats
por: Gao, Lei, et al.
Publicado: (2023)

Targeting PI3K/Akt/mTOR Signaling in Cancer
por: Porta, Camillo, et al.
Publicado: (2014)

PI3K/Akt/mTOR inhibitors in breast cancer
por: Lee, Joycelyn JX, et al.
Publicado: (2015)

Nuciferine induces autophagy to relieve vascular cell adhesion molecule 1 activation via repressing the Akt/mTOR/AP1 signal pathway in the vascular endothelium
por: Wei, Haibin, et al.
Publicado: (2023)

Silencing c-Jun inhibits autophagy and abrogates radioresistance in nasopharyngeal carcinoma by activating the PI3K/AKT/mTOR pathway
por: Sun, Yongchu, et al.
Publicado: (2021)

Silencing DTX3L Inhibits the Progression of Cervical Carcinoma by Regulating PI3K/AKT/mTOR Signaling Pathway
por: Hu, Wei, et al.
Publicado: (2023)

Genetic variants in ADAM33 are associated with airway inflammation and lung function in COPD
por: Wang, Xinyan, et al.
Publicado: (2014)

Luteolin Ameliorates Hypertensive Vascular Remodeling through Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells
por: Su, Jie, et al.
Publicado: (2015)

Retraction: PTEN gene silencing contributes to airway remodeling and induces airway smooth muscle cell proliferation in mice with allergic asthma
Publicado: (2022)

Engineering Smooth Muscle to Understand Extracellular Matrix Remodeling and Vascular Disease
por: Yarbrough, Danielle, et al.
Publicado: (2022)

SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling
por: Xu, Yue, et al.
Publicado: (2023)

EGCG protects vascular endothelial cells from oxidative stress-induced damage by targeting the autophagy-dependent PI3K-AKT-mTOR pathway
por: Meng, Jiao, et al.
Publicado: (2020)

Danlou Tablet Activates Autophagy of Vascular Adventitial Fibroblasts Through PI3K/Akt/mTOR to Protect Cells From Damage Caused by Atherosclerosis
por: Wang, Li, et al.
Publicado: (2021)

mTOR Signaling in Pulmonary Vascular Disease: Pathogenic Role and Therapeutic Target
por: Babicheva, Aleksandra, et al.
Publicado: (2021)

Role of Inhaled Steroids in Vascular Airway Remodelling in Asthma and COPD
por: Chetta, Alfredo, et al.
Publicado: (2012)

Silencing UHRF1 Enhances Radiosensitivity of Esophageal Squamous Cell Carcinoma by Inhibiting the PI3K/Akt/mTOR Signaling Pathway
por: Hui, Beina, et al.
Publicado: (2021)

Effect of active vitamin D3 on VEGF-induced ADAM33 expression and proliferation in human airway smooth muscle cells: implications for asthma treatment
por: Kim, Sung-Ho, et al.
Publicado: (2017)

ADAM9 promotes lung cancer progression through vascular remodeling by VEGFA, ANGPT2, and PLAT
por: Lin, Chen-Yuan, et al.
Publicado: (2017)

Editorial: Vascular smooth muscle cell fate and vascular remodeling: Mechanisms, therapeutic targets, and drugs, volume I
por: Wang, Qilong, et al.
Publicado: (2022)

Gasdermin D affects aortic vascular smooth muscle cell pyroptosis and Ang II-induced vascular remodeling
por: Fang, Zimin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_umjbgtmibvl2svahm5irlvdasm