Tromethamine improves mucociliary clearance in cystic fibrosis pigs

In cystic fibrosis (CF), the loss of cystic fibrosis transmembrane conductance regulator (CFTR) mediated Cl(− )and HCO(3) (−) secretion across the epithelium acidifies the airway surface liquid (ASL). Acidic ASL alters two key host defense mechanisms: Rapid ASL bacterial killing and mucociliary tran...

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Detalles Bibliográficos
Autores principales: Ash, Jamison J., Hilkin, Brieanna M., Gansemer, Nicholas D., Hoffman, Eric A., Zabner, Joseph, Stoltz, David A., Abou Alaiwa, Mahmoud H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453173/
https://www.ncbi.nlm.nih.gov/pubmed/36073059
http://dx.doi.org/10.14814/phy2.15340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453173/
https://www.ncbi.nlm.nih.gov/pubmed/36073059
http://dx.doi.org/10.14814/phy2.15340

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