Blockade of Mbd2 by siRNA-loaded liposomes protects mice against OVA-induced allergic airway inflammation via repressing M2 macrophage production

OBJECTIVE: To address the role of methyl-CpG-binding domain 2 (MBD2) in the pathogenesis of asthma and its potential as a target for the asthmatic therapy. METHODS: Studies were conducted in asthmatic patients and macrophage-specific Mbd2 knockout mice to dissect the role of MBD2 in asthma pathogene...

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Detalles Bibliográficos
Autores principales: Wu, Guo-Rao, Zhou, Min, Wang, Yi, Zhou, Qing, Zhang, Lei, He, Long, Zhang, Shu, Yu, Qilin, Xu, Yongjian, Zhao, Jianping, Xiong, Weining, Wang, Cong-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453648/
https://www.ncbi.nlm.nih.gov/pubmed/36090987
http://dx.doi.org/10.3389/fimmu.2022.930103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453648/
https://www.ncbi.nlm.nih.gov/pubmed/36090987
http://dx.doi.org/10.3389/fimmu.2022.930103

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