A novel cyclic γ-AApeptide-based long-acting pan-coronavirus fusion inhibitor with potential oral bioavailability by targeting two sites in spike protein

The receptor-binding domain (RBD) in S1 subunit and heptad repeat 1 (HR1) domain in S2 subunit of SARS-CoV-2 spike (S) protein are the targets of neutralizing antibodies (nAbs) and pan-coronavirus (CoV) fusion inhibitory peptides, respectively. However, neither nAb- nor peptide-based drugs can be us...

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Detalles Bibliográficos
Autores principales: Xue, Songyi, Wang, Xinling, Wang, Lei, Xu, Wei, Xia, Shuai, Sun, Lujia, Wang, Shaohui, Shen, Ning, Yang, Ziqi, Huang, Bo, Li, Sihao, Cao, Chuanhai, Calcul, Laurent, Sun, Xingmin, Lu, Lu, Cai, Jianfeng, Jiang, Shibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453727/
https://www.ncbi.nlm.nih.gov/pubmed/36075899
http://dx.doi.org/10.1038/s41421-022-00455-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453727/
https://www.ncbi.nlm.nih.gov/pubmed/36075899
http://dx.doi.org/10.1038/s41421-022-00455-6

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