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A novel cyclic γ-AApeptide-based long-acting pan-coronavirus fusion inhibitor with potential oral bioavailability by targeting two sites in spike protein
The receptor-binding domain (RBD) in S1 subunit and heptad repeat 1 (HR1) domain in S2 subunit of SARS-CoV-2 spike (S) protein are the targets of neutralizing antibodies (nAbs) and pan-coronavirus (CoV) fusion inhibitory peptides, respectively. However, neither nAb- nor peptide-based drugs can be us...
Autores principales: | Xue, Songyi, Wang, Xinling, Wang, Lei, Xu, Wei, Xia, Shuai, Sun, Lujia, Wang, Shaohui, Shen, Ning, Yang, Ziqi, Huang, Bo, Li, Sihao, Cao, Chuanhai, Calcul, Laurent, Sun, Xingmin, Lu, Lu, Cai, Jianfeng, Jiang, Shibo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453727/ https://www.ncbi.nlm.nih.gov/pubmed/36075899 http://dx.doi.org/10.1038/s41421-022-00455-6 |
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