Cargando…

A novel cyclic γ-AApeptide-based long-acting pan-coronavirus fusion inhibitor with potential oral bioavailability by targeting two sites in spike protein

The receptor-binding domain (RBD) in S1 subunit and heptad repeat 1 (HR1) domain in S2 subunit of SARS-CoV-2 spike (S) protein are the targets of neutralizing antibodies (nAbs) and pan-coronavirus (CoV) fusion inhibitory peptides, respectively. However, neither nAb- nor peptide-based drugs can be us...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xue, Songyi, Wang, Xinling, Wang, Lei, Xu, Wei, Xia, Shuai, Sun, Lujia, Wang, Shaohui, Shen, Ning, Yang, Ziqi, Huang, Bo, Li, Sihao, Cao, Chuanhai, Calcul, Laurent, Sun, Xingmin, Lu, Lu, Cai, Jianfeng, Jiang, Shibo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Nature Singapore 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453727/ https://www.ncbi.nlm.nih.gov/pubmed/36075899 http://dx.doi.org/10.1038/s41421-022-00455-6

Ejemplares similares

An HR2-Mimicking Sulfonyl-γ-AApeptide Is a Potent Pan-coronavirus Fusion Inhibitor with Strong Blood–Brain Barrier Permeability, Long Half-Life, and Promising Oral Bioavailability
por: Xue, Songyi, et al.
Publicado: (2023)

Short, Lipidated Dendrimeric γ-AApeptides as New Antimicrobial Peptidomimetics
por: Wang, Yafeng, et al.
Publicado: (2023)

Dimeric γ-AApeptides With Potent and Selective Antibacterial Activity
por: Wang, Minghui, et al.
Publicado: (2020)

Helical sulfono-γ-AApeptides with predictable functions in protein recognition
por: Sang, Peng, et al.
Publicado: (2022)

γ-AApeptides–based Small Molecule Ligands That Disaggregate Human Islet Amyloid Polypeptide
por: Bolarinwa, Olapeju, et al.
Publicado: (2020)

The activity of sulfono-γ-AApeptide helical foldamers that mimic GLP-1
por: Sang, Peng, et al.
Publicado: (2020)

α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53–MDM2/MDMX Protein–Protein Interactions
por: Sang, Peng, et al.
Publicado: (2020)

Correction to α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53–MDM2/MDMX Protein–Protein Interactions
por: Sang, Peng, et al.
Publicado: (2020)

An engineered recombinant protein containing three structural domains in SARS-CoV-2 S2 protein has potential to act as a pan-human coronavirus entry inhibitor or vaccine antigen
por: Wang, Xinling, et al.
Publicado: (2023)

Pan-coronavirus fusion inhibitors as the hope for today and tomorrow
por: Wang, Xinling, et al.
Publicado: (2021)

Potential recombination between SARS-CoV-2 and MERS-CoV: calls for the development of Pan-CoV vaccines
por: Wang, Qiao, et al.
Publicado: (2023)

An Artificial Peptide-Based Bifunctional HIV-1 Entry Inhibitor That Interferes with Viral Glycoprotein-41 Six-Helix Bundle Formation and Antagonizes CCR5 on the Host Cell Membrane
por: Wang, Chao, et al.
Publicado: (2023)

Retraction Note to: SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion
por: Wang, Xinling, et al.
Publicado: (2020)

RETRACTED ARTICLE: SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion
por: Wang, Xinling, et al.
Publicado: (2020)

A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike
por: Xia, Shuai, et al.
Publicado: (2019)

FliW and CsrA Govern Flagellin (FliC) Synthesis and Play Pleiotropic Roles in Virulence and Physiology of Clostridioides difficile R20291
por: Zhu, Duolong, et al.
Publicado: (2021)

Development of an Effective Nontoxigenic Clostridioides difficile–Based Oral Vaccine against C. difficile Infection
por: Wang, Shaohui, et al.
Publicado: (2022)

The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin
por: Xia, Shuai, et al.
Publicado: (2020)

Cyclic Glucans Enhance Solubility of Bioavailable Flavonoids
por: Park, Seyeon
Publicado: (2016)

SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread
por: Wang, Xinling, et al.
Publicado: (2023)

IgG Fc-Binding Peptide-Conjugated Pan-CoV Fusion Inhibitor Exhibits Extended In Vivo Half-Life and Synergistic Antiviral Effect When Combined with Neutralizing Antibodies
por: Su, Xiaojie, et al.
Publicado: (2023)

Genomic and Phenotypic Characterization of the Nontoxigenic Clostridioides difficile Strain CCUG37785 and Demonstration of Its Therapeutic Potential for the Prevention of C. difficile Infection
por: Wang, Shaohui, et al.
Publicado: (2022)

SARS-CoV-2 Omicron subvariants exhibit distinct fusogenicity, but similar sensitivity, to pan-CoV fusion inhibitors
por: Xia, Shuai, et al.
Publicado: (2023)

A pan-sarbecovirus vaccine based on RBD of SARS-CoV-2 original strain elicits potent neutralizing antibodies against XBB in non-human primates
por: Liu, Zezhong, et al.
Publicado: (2023)

Pan-coronavirus epitope buried in spike
por: Hofer, Ursula
Publicado: (2022)

The putative mechanism of lymphopenia in COVID-19 patients
por: Wang, Xinling, et al.
Publicado: (2022)

Modulation of Oral Bioavailability and Metabolism for Closely Related Cyclic Hexapeptides
por: Vorherr, Thomas, et al.
Publicado: (2017)

Novel Chimeric Protein Vaccines Against Clostridium difficile Infection
por: Wang, Shaohui, et al.
Publicado: (2018)

Comprehensive Landscape of RRM2 with Immune Infiltration in Pan-Cancer
por: Zhou, Zijian, et al.
Publicado: (2022)

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds
por: White, Tina R., et al.
Publicado: (2011)

A Novel Bacteriophage Lysin-Human Defensin Fusion Protein Is Effective in Treatment of Clostridioides difficile Infection in Mice
por: Peng, Zhong, et al.
Publicado: (2019)

Exploring the oncogenic roles of LINC00857 in pan-cancer
por: Ren, Xiaomin, et al.
Publicado: (2022)

Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein
por: Xia, Shuai, et al.
Publicado: (2014)

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion
por: Xia, Shuai, et al.
Publicado: (2020)

Pan-Cancer Analysis of Pentraxin 3: A Potential Biomarker of COVID-19
por: Zhou, Zijian, et al.
Publicado: (2022)

Lymphocyte integrins mediate entry and dysregulation of T cells by SARS-CoV-2
por: Huang, Mengwen, et al.
Publicado: (2023)

Griffithsin with A Broad-Spectrum Antiviral Activity by Binding Glycans in Viral Glycoprotein Exhibits Strong Synergistic Effect in Combination with A Pan-Coronavirus Fusion Inhibitor Targeting SARS-CoV-2 Spike S2 Subunit
por: Cai, Yanxing, et al.
Publicado: (2020)

A hierarchical spike-and-slab model for pan-cancer survival using pan-omic data
por: Samorodnitsky, Sarah, et al.
Publicado: (2022)

Engineered trimeric ACE2 binds viral spike protein and locks it in “Three-up” conformation to potently inhibit SARS-CoV-2 infection
por: Guo, Liang, et al.
Publicado: (2020)

A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs
por: Liu, Zezhong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tku513u8po1aj6oh02q2imu3bf