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Protein Unfolding in Freeze Frames: Intermediate States are Revealed by Variable-Temperature Ion Mobility–Mass Spectrometry

[Image: see text] The gas phase is an idealized laboratory for the study of protein structure, from which it is possible to examine stable and transient forms of mass-selected ions in the absence of bulk solvent. With ion mobility–mass spectrometry (IM-MS) apparatus built to operate at both cryogeni...

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Detalles Bibliográficos
Autores principales: Ujma, Jakub, Jhingree, Jacquelyn, Norgate, Emma, Upton, Rosie, Wang, Xudong, Benoit, Florian, Bellina, Bruno, Barran, Perdita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453741/
https://www.ncbi.nlm.nih.gov/pubmed/36001095
http://dx.doi.org/10.1021/acs.analchem.2c03066