Combined Pulsed Electron Double Resonance EPR and Molecular Dynamics Investigations of Calmodulin Suggest Effects of Crowding Agents on Protein Structures

[Image: see text] Calmodulin (CaM) is a highly dynamic Ca(2+)-binding protein that exhibits large conformational changes upon binding Ca(2+) and target proteins. Although it is accepted that CaM exists in an equilibrium of conformational states in the absence of target protein, the physiological rel...

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Detalles Bibliográficos
Autores principales: Stewart, Andrew M., Shanmugam, Muralidharan, Kutta, Roger J., Scrutton, Nigel S., Lovett, Janet E., Hay, Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454100/
https://www.ncbi.nlm.nih.gov/pubmed/35979922
http://dx.doi.org/10.1021/acs.biochem.2c00099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454100/
https://www.ncbi.nlm.nih.gov/pubmed/35979922
http://dx.doi.org/10.1021/acs.biochem.2c00099

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