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THZ1 targeting CDK7 suppresses c-KIT transcriptional activity in gastrointestinal stromal tumours
BACKGROUND: Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the gastrointestinal tract and are characterized by activating mutations of c-KIT or PDGFRa receptor tyrosine kinases (RTKs). Despite the clinical success of tyrosine kinase inhibitors (TKIs), more than h...
| Κύριοι συγγραφείς: | , , , , , |
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| Μορφή: | Online Άρθρο Κείμενο |
| Γλώσσα: | English |
| Έκδοση: |
BioMed Central
2022
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| Θέματα: | |
| Διαθέσιμο Online: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454178/ https://www.ncbi.nlm.nih.gov/pubmed/36076237 http://dx.doi.org/10.1186/s12964-022-00928-x |