THZ1 targeting CDK7 suppresses c-KIT transcriptional activity in gastrointestinal stromal tumours

BACKGROUND: Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the gastrointestinal tract and are characterized by activating mutations of c-KIT or PDGFRa receptor tyrosine kinases (RTKs). Despite the clinical success of tyrosine kinase inhibitors (TKIs), more than h...

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Detalles Bibliográficos
Autores principales: Sun, Jianyi, Zhang, Qiang, Sun, Xiangfei, Xue, Anwei, Gao, Xiaodong, Shen, Kuntang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454178/
https://www.ncbi.nlm.nih.gov/pubmed/36076237
http://dx.doi.org/10.1186/s12964-022-00928-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454178/
https://www.ncbi.nlm.nih.gov/pubmed/36076237
http://dx.doi.org/10.1186/s12964-022-00928-x

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