An Epitope-Specific LGI1-Autoantibody Enhances Neuronal Excitability by Modulating Kv1.1 Channel

Leucine-rich Glioma-Inactivated protein 1 (LGI1) is expressed in the central nervous system and its genetic loss of function is associated with epileptic disorders. Additionally, patients with LGI1-directed autoantibodies have frequent focal seizures as a key feature of their disease. LGI1 is compos...

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Detalles Bibliográficos
Autores principales: Extrémet, Johanna, El Far, Oussama, Ankri, Norbert, Irani, Sarosh R., Debanne, Dominique, Russier, Michaël
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454693/
https://www.ncbi.nlm.nih.gov/pubmed/36078121
http://dx.doi.org/10.3390/cells11172713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454693/
https://www.ncbi.nlm.nih.gov/pubmed/36078121
http://dx.doi.org/10.3390/cells11172713

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