Cargando…

An Epitope-Specific LGI1-Autoantibody Enhances Neuronal Excitability by Modulating Kv1.1 Channel

Leucine-rich Glioma-Inactivated protein 1 (LGI1) is expressed in the central nervous system and its genetic loss of function is associated with epileptic disorders. Additionally, patients with LGI1-directed autoantibodies have frequent focal seizures as a key feature of their disease. LGI1 is compos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Extrémet, Johanna, El Far, Oussama, Ankri, Norbert, Irani, Sarosh R., Debanne, Dominique, Russier, Michaël
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454693/ https://www.ncbi.nlm.nih.gov/pubmed/36078121 http://dx.doi.org/10.3390/cells11172713

Ejemplares similares

Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms
por: Ramberger, Melanie, et al.
Publicado: (2020)

Comparative Effects of Domain-Specific Human Monoclonal Antibodies Against LGI1 on Neuronal Excitability
por: Sell, Josefine, et al.
Publicado: (2023)

LGI1 expression and human brain asymmetry: insights from patients with LGI1-antibody encephalitis
por: Jang, Yoonhyuk, et al.
Publicado: (2018)

Theta patterns of stimulation induce synaptic and intrinsic potentiation in O-LM interneurons
por: Sammari, Malika, et al.
Publicado: (2022)

Treating seizures and preventing amnesia in LGI1-antibody encephalitis: A new MRI signature?
por: Varley, James A., et al.
Publicado: (2015)

Plasticity of intrinsic excitability during LTD is mediated by bidirectional changes in h-channel activity
por: Gasselin, Célia, et al.
Publicado: (2017)

The role of axonal Kv1 channels in CA3 pyramidal cell excitability
por: Rama, Sylvain, et al.
Publicado: (2017)

LGI1-antibody encephalitis is characterised by frequent, multifocal clinical and subclinical seizures
por: Aurangzeb, Sidra, et al.
Publicado: (2017)

LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes
por: Binks, Sophie N M, et al.
Publicado: (2018)

Basal ganglia T1 hyperintensity in LGI1-autoantibody faciobrachial dystonic seizures
por: Flanagan, Eoin P., et al.
Publicado: (2015)

LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11
por: Sagane, Koji, et al.
Publicado: (2008)

A fast Markovian method for modeling channel noise in neurons
por: Ankri, Norbert, et al.
Publicado: (2023)

Intrathecal B-cell activation in LGI1 antibody encephalitis
por: Lehmann-Horn, Klaus, et al.
Publicado: (2020)

Case Report: Anti-LGI1 Limbic Encephalitis Associated With Anti-thyroid Autoantibodies
por: Otiniano-Sifuentes, Ricardo, et al.
Publicado: (2021)

Distinct HLA associations of LGI1 and CASPR2-antibody diseases
por: Binks, Sophie, et al.
Publicado: (2018)

Psychiatric Manifestation of Anti-LGI1 Encephalitis
por: Endres, Dominique, et al.
Publicado: (2020)

Thymoma-associated anti-LGI1 encephalitis and myasthenia gravis: A unique combination with autoantibodies
por: Satake, Akane, et al.
Publicado: (2022)

Randomized Placebo‐Controlled Trial of Intravenous Immunoglobulin in Autoimmune LGI1/CASPR2 Epilepsy
por: Dubey, Divyanshu, et al.
Publicado: (2019)

LGI3/2–ADAM23 interactions cluster Kv1 channels in myelinated axons to regulate refractory period
por: Kozar-Gillan, Nina, et al.
Publicado: (2023)

Positive LGI1 Antibodies in CSF and Relapse Relate to Worse Outcome in Anti-LGI1 Encephalitis
por: Cui, Li-li, et al.
Publicado: (2021)

Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo
por: Morgan, Peter James, et al.
Publicado: (2019)

LGI1-antibody associated epilepsy successfully treated in the outpatient setting
por: Uribe-San-Martín, R., et al.
Publicado: (2020)

Focal CA3 hippocampal subfield atrophy following LGI1 VGKC-complex antibody limbic encephalitis
por: Miller, Thomas D., et al.
Publicado: (2017)

Mechanisms of Plasticity in Subcortical Visual Areas
por: Duménieu, Maël, et al.
Publicado: (2021)

Oligomerization and Spatial Distribution of Kvβ1.1 and Kvβ2.1 Regulatory Subunits
por: Roig, Sara R., et al.
Publicado: (2022)

Human Leukocyte Antigen Association Study Reveals DRB1*04:02 Effects Additional to DRB1*07:01 in Anti-LGI1 Encephalitis
por: Peris Sempere, Vicente, et al.
Publicado: (2022)

Isolated Chorea Associated with LGI1 Antibody
por: Ramdhani, Ritesh A., et al.
Publicado: (2014)

Striatum Involvement in LGI1 Limbic Encephalitis
por: Plantone, Domenico
Publicado: (2018)

An Unusual Case of LGI1 (Leucine-Rich Glioma-Inactivated Protein 1) Limbic Encephalitis With Anti-acetylcholine Receptor and Anti-striational Autoantibodies
por: Pathak, Akash, et al.
Publicado: (2023)

Identification of genetic variants of LGI1 and RTN4R (NgR1) linked to schizophrenia that are defective in NgR1–LGI1 signaling
por: Thomas, Rhalena A., et al.
Publicado: (2016)

Kv1.1 Channelopathies: Pathophysiological Mechanisms and Therapeutic Approaches
por: D’Adamo, Maria Cristina, et al.
Publicado: (2020)

Kv1.1 channel subunits in the control of neurocardiac function
por: Glasscock, Edward
Publicado: (2019)

Similarity of molecular phenotype between known epilepsy gene LGI1 and disease candidate gene LGI2
por: Limviphuvadh, Vachiranee, et al.
Publicado: (2010)

A truncated Kv1.1 protein in the brain of the megencephaly mouse: expression and interaction
por: Persson, Ann-Sophie, et al.
Publicado: (2005)

Redistribution of Kv1 and Kv7 enhances neuronal excitability during structural axon initial segment plasticity
por: Kuba, Hiroshi, et al.
Publicado: (2015)

Hyponatraemia caused by LGI1-associated limbic encephalitis
por: McQuillan, Rory F., et al.
Publicado: (2011)

Clinical features of limbic encephalitis with LGI1 antibody
por: Wang, Meiling, et al.
Publicado: (2017)

Pilomotor Seizures in a Patient With LGI1 Encephalitis
por: Yang, Jinxia, et al.
Publicado: (2020)

Flortaucipir (tau) PET in LGI1 antibody encephalitis
por: Day, Gregory S., et al.
Publicado: (2021)

LGI1 Encephalitis: Autoimmune Epilepsy or Movement Disorder
por: Jagtap, Sujit A., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_i81nl3ij8s3cjh7952orsfv9ni