Demonstrating Tumor Vascular Disrupting Activity of the Small-Molecule Dihydronaphthalene Tubulin-Binding Agent OXi6196 as a Potential Therapeutic for Cancer Treatment

SIMPLE SUMMARY: Vascular-disrupting agents promise significant therapeutic efficacy against solid tumors by selectively damaging tumor-associated vasculature. Following administration of the phosphate prodrug OXi6197, dynamic bioluminescence imaging revealed dose-responsive vascular shutdown in MDA-...

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Detalles Bibliográficos
Autores principales: Liu, Li, Schuetze, Regan, Gerberich, Jeni L., Lopez, Ramona, Odutola, Samuel O., Tanpure, Rajendra P., Charlton-Sevcik, Amanda K., Tidmore, Justin K., Taylor, Emily A.-S., Kapur, Payal, Hammers, Hans, Trawick, Mary Lynn, Pinney, Kevin G., Mason, Ralph P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454770/
https://www.ncbi.nlm.nih.gov/pubmed/36077745
http://dx.doi.org/10.3390/cancers14174208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454770/
https://www.ncbi.nlm.nih.gov/pubmed/36077745
http://dx.doi.org/10.3390/cancers14174208

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