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Demonstrating Tumor Vascular Disrupting Activity of the Small-Molecule Dihydronaphthalene Tubulin-Binding Agent OXi6196 as a Potential Therapeutic for Cancer Treatment

SIMPLE SUMMARY: Vascular-disrupting agents promise significant therapeutic efficacy against solid tumors by selectively damaging tumor-associated vasculature. Following administration of the phosphate prodrug OXi6197, dynamic bioluminescence imaging revealed dose-responsive vascular shutdown in MDA-...

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Detalles Bibliográficos
Autores principales:	Liu, Li, Schuetze, Regan, Gerberich, Jeni L., Lopez, Ramona, Odutola, Samuel O., Tanpure, Rajendra P., Charlton-Sevcik, Amanda K., Tidmore, Justin K., Taylor, Emily A.-S., Kapur, Payal, Hammers, Hans, Trawick, Mary Lynn, Pinney, Kevin G., Mason, Ralph P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454770/ https://www.ncbi.nlm.nih.gov/pubmed/36077745 http://dx.doi.org/10.3390/cancers14174208

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