Targeting Anti-Angiogenic VEGF(165)b–VEGFR1 Signaling Promotes Nitric Oxide Independent Therapeutic Angiogenesis in Preclinical Peripheral Artery Disease Models

Nitric oxide (NO) is the critical regulator of VEGFR2-induced angiogenesis. Neither VEGF-A over-expression nor L-Arginine (NO-precursor) supplementation has been effective in helping patients with Peripheral Artery Disease (PAD) in clinical trials. One incompletely studied reason may be due to the p...

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Detalles Bibliográficos
Autores principales: Kuppuswamy, Sivaraman, Annex, Brian H., Ganta, Vijay C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454804/
https://www.ncbi.nlm.nih.gov/pubmed/36078086
http://dx.doi.org/10.3390/cells11172676

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454804/
https://www.ncbi.nlm.nih.gov/pubmed/36078086
http://dx.doi.org/10.3390/cells11172676

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