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Proteogenomics and Differential Ion Mobility Enable the Exploration of the Mutational Landscape in Colon Cancer Cells

[Image: see text] The sensitivity and depth of proteomic analyses are limited by isobaric ions and interferences that preclude the identification of low abundance peptides. Extensive sample fractionation is often required to extend proteome coverage when sample amount is not a limitation. Ion mobili...

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Detalles Bibliográficos
Autores principales: Wu, Zhaoguan, Bonneil, Éric, Belford, Michael, Boeser, Cornelia, Ruiz Cuevas, Maria Virginia, Lemieux, Sébastien, Dunyach, Jean-Jacques, Thibault, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454824/
https://www.ncbi.nlm.nih.gov/pubmed/35995421
http://dx.doi.org/10.1021/acs.analchem.2c02056