Metformin with Temozolomide for Newly Diagnosed Glioblastoma: Results of Phase I Study and a Brief Review of Relevant Studies

SIMPLE SUMMARY: Glioblastoma is an incurable disease, demanding new therapeutic approaches. Our preclinical studies proved that the antidiabetic drug metformin could induce the differentiation of stem-like glioma-initiating cells and suppress tumor formation through AMPK-FOXO3 activation, suggesting...

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Detalles Bibliográficos
Autores principales: Ohno, Makoto, Kitanaka, Chifumi, Miyakita, Yasuji, Tanaka, Shota, Sonoda, Yukihiko, Mishima, Kazuhiko, Ishikawa, Eiichi, Takahashi, Masamichi, Yanagisawa, Shunsuke, Ohashi, Ken, Nagane, Motoo, Narita, Yoshitaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454846/
https://www.ncbi.nlm.nih.gov/pubmed/36077758
http://dx.doi.org/10.3390/cancers14174222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454846/
https://www.ncbi.nlm.nih.gov/pubmed/36077758
http://dx.doi.org/10.3390/cancers14174222

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