BMS-986158, a Small Molecule Inhibitor of the Bromodomain and Extraterminal Domain Proteins, in Patients with Selected Advanced Solid Tumors: Results from a Phase 1/2a Trial

SIMPLE SUMMARY: Bromodomain and extraterminal domain (BET) proteins can regulate cancer-related genes to make tumors grow. BMS-986158, an experimental anticancer therapy, blocks BET protein function. We researched BMS-986158′s potential anticancer effects, side effects, what happens to BMS-986158 in...

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Detalles Bibliográficos
Autores principales: Hilton, John, Cristea, Mihaela, Postel-Vinay, Sophie, Baldini, Capucine, Voskoboynik, Mark, Edenfield, William, Shapiro, Geoffrey I., Cheng, Michael L., Vuky, Jacqueline, Corr, Bradley, Das, Sharmila, Apfel, Abraham, Xu, Ke, Kozicki, Martin, Ünsal-Kaçmaz, Keziban, Hammell, Amy, Wang, Guan, Ravindran, Palanikumar, Kollia, Georgia, Esposito, Oriana, Coker, Shodeinde, Diamond, Jennifer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454848/
https://www.ncbi.nlm.nih.gov/pubmed/36077617
http://dx.doi.org/10.3390/cancers14174079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454848/
https://www.ncbi.nlm.nih.gov/pubmed/36077617
http://dx.doi.org/10.3390/cancers14174079

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