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Pramlintide: A Novel Therapeutic Approach for Osteosarcoma through Metabolic Reprogramming

SIMPLE SUMMARY: Outcomes for patients with osteosarcoma have remained stagnant for more than 3 decades. Novel therapeutic agents are desperately needed. Osteosarcoma cells often express abnormal form of the p53, p63, and p73 genes, which promote glucose uptake, cell glycolysis, and rapid proliferati...

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Detalles Bibliográficos
Autores principales: Yang, Yuanzheng, Peng, Zhanglong, Flores, Elsa R., Kleinerman, Eugenie S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454976/
https://www.ncbi.nlm.nih.gov/pubmed/36077845
http://dx.doi.org/10.3390/cancers14174310