Novel UHRF1-MYC Axis in Acute Lymphoblastic Leukemia

SIMPLE SUMMARY: We provided evidence that ubiquitin-like, containing PHD and RING finger domain, 1 (UHRF1) is overexpressed in acute lymphocytic leukemia (ALL). We further showed that UHRF1 directly interacts and regulates c-Myc expression to enable ALL cell growth through the cMYC-CDK4/6 phosphoRb-...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Soyoung, Sater, Ali H. Abdel, Fahrmann, Johannes F., Irajizad, Ehsan, Cai, Yining, Katayama, Hiroyuki, Vykoukal, Jody, Kobayashi, Makoto, Dennison, Jennifer B., Garcia-Manero, Guillermo, Mullighan, Charles G., Gu, Zhaohui, Konopleva, Marina, Hanash, Samir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455066/
https://www.ncbi.nlm.nih.gov/pubmed/36077796
http://dx.doi.org/10.3390/cancers14174262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455066/
https://www.ncbi.nlm.nih.gov/pubmed/36077796
http://dx.doi.org/10.3390/cancers14174262

Ejemplares similares