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Novel UHRF1-MYC Axis in Acute Lymphoblastic Leukemia

SIMPLE SUMMARY: We provided evidence that ubiquitin-like, containing PHD and RING finger domain, 1 (UHRF1) is overexpressed in acute lymphocytic leukemia (ALL). We further showed that UHRF1 directly interacts and regulates c-Myc expression to enable ALL cell growth through the cMYC-CDK4/6 phosphoRb-...

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Detalles Bibliográficos
Autores principales:	Park, Soyoung, Sater, Ali H. Abdel, Fahrmann, Johannes F., Irajizad, Ehsan, Cai, Yining, Katayama, Hiroyuki, Vykoukal, Jody, Kobayashi, Makoto, Dennison, Jennifer B., Garcia-Manero, Guillermo, Mullighan, Charles G., Gu, Zhaohui, Konopleva, Marina, Hanash, Samir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455066/ https://www.ncbi.nlm.nih.gov/pubmed/36077796 http://dx.doi.org/10.3390/cancers14174262

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