A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling

Alterations in both the expression and function of the non-receptor tyrosine kinase Zap70 are associated with numerous human diseases including immunodeficiency, autoimmunity, and leukemia. Zap70 propagates the TCR signal by phosphorylating two important adaptor molecules, LAT and SLP76, which orche...

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Detalles Bibliográficos
Autores principales: Schultz, Annika, Schnurra, Marvin, El-Bizri, Ali, Woessner, Nadine M., Hartmann, Sara, Hartig, Roland, Minguet, Susana, Schraven, Burkhart, Simeoni, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455082/
https://www.ncbi.nlm.nih.gov/pubmed/36078131
http://dx.doi.org/10.3390/cells11172723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455082/
https://www.ncbi.nlm.nih.gov/pubmed/36078131
http://dx.doi.org/10.3390/cells11172723

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