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A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling
Alterations in both the expression and function of the non-receptor tyrosine kinase Zap70 are associated with numerous human diseases including immunodeficiency, autoimmunity, and leukemia. Zap70 propagates the TCR signal by phosphorylating two important adaptor molecules, LAT and SLP76, which orche...
Autores principales: | Schultz, Annika, Schnurra, Marvin, El-Bizri, Ali, Woessner, Nadine M., Hartmann, Sara, Hartig, Roland, Minguet, Susana, Schraven, Burkhart, Simeoni, Luca |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455082/ https://www.ncbi.nlm.nih.gov/pubmed/36078131 http://dx.doi.org/10.3390/cells11172723 |
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