Design, synthesis, and biological evaluation of potent FAK-degrading PROTACs

FAK mediated tumour cell migration, invasion, survival, proliferation and regulation of tumour stem cells through its kinase-dependent enzymatic functions and kinase-independent scaffolding functions. At present, the development of FAK PROTACs has become one of the hotspots in current pharmaceutical...

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Detalles Bibliográficos
Autores principales: Qin, Qiaohua, Wang, Ruifeng, Fu, Qinglin, Zhang, Guoqi, Wu, Tianxiao, Liu, Nian, Lv, Ruicheng, Yin, Wenbo, Sun, Yin, Sun, Yixiang, Zhao, Dongmei, Cheng, Maosheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455338/
https://www.ncbi.nlm.nih.gov/pubmed/35978496
http://dx.doi.org/10.1080/14756366.2022.2100886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455338/
https://www.ncbi.nlm.nih.gov/pubmed/35978496
http://dx.doi.org/10.1080/14756366.2022.2100886

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