Discovery of 4-nitro-3-phenylisoxazole derivatives as potent antibacterial agents derived from the studies of [3 + 2] cycloaddition

Polysubstituted phenylisoxazoles were designed and synthesized to discover new antibacterial agents via [3 + 2] cycloaddition. Thirty-five compounds with a phenylisoxazole scaffold were characterized by NMR, HRMS, and X-ray techniques. After being evaluated against Xanthomonas oryzae (Xoo), Pseudomo...

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Detalles Bibliográficos
Autores principales: Zhang, Yan, Long, Zhiwu, Yan, Longjia, Liu, Li, Yang, Lan, Le, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455768/
https://www.ncbi.nlm.nih.gov/pubmed/36199305
http://dx.doi.org/10.1039/d2ra05009a
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author Zhang, Yan
Long, Zhiwu
Yan, Longjia
Liu, Li
Yang, Lan
Le, Yi
author_facet Zhang, Yan
Long, Zhiwu
Yan, Longjia
Liu, Li
Yang, Lan
Le, Yi
author_sort Zhang, Yan
collection PubMed
description Polysubstituted phenylisoxazoles were designed and synthesized to discover new antibacterial agents via [3 + 2] cycloaddition. Thirty-five compounds with a phenylisoxazole scaffold were characterized by NMR, HRMS, and X-ray techniques. After being evaluated against Xanthomonas oryzae (Xoo), Pseudomonas syringae (Psa), and Xanthomonas axonopodis (Xac), 4-nitro-3-phenylisoxazole derivatives were found to better antibacterial activities. Further studies have shown that the EC(50) values of these compounds were much better than that of the positive control, bismerthiazol.
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spelling pubmed-94557682022-10-04 Discovery of 4-nitro-3-phenylisoxazole derivatives as potent antibacterial agents derived from the studies of [3 + 2] cycloaddition Zhang, Yan Long, Zhiwu Yan, Longjia Liu, Li Yang, Lan Le, Yi RSC Adv Chemistry Polysubstituted phenylisoxazoles were designed and synthesized to discover new antibacterial agents via [3 + 2] cycloaddition. Thirty-five compounds with a phenylisoxazole scaffold were characterized by NMR, HRMS, and X-ray techniques. After being evaluated against Xanthomonas oryzae (Xoo), Pseudomonas syringae (Psa), and Xanthomonas axonopodis (Xac), 4-nitro-3-phenylisoxazole derivatives were found to better antibacterial activities. Further studies have shown that the EC(50) values of these compounds were much better than that of the positive control, bismerthiazol. The Royal Society of Chemistry 2022-09-08 /pmc/articles/PMC9455768/ /pubmed/36199305 http://dx.doi.org/10.1039/d2ra05009a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhang, Yan
Long, Zhiwu
Yan, Longjia
Liu, Li
Yang, Lan
Le, Yi
Discovery of 4-nitro-3-phenylisoxazole derivatives as potent antibacterial agents derived from the studies of [3 + 2] cycloaddition
title Discovery of 4-nitro-3-phenylisoxazole derivatives as potent antibacterial agents derived from the studies of [3 + 2] cycloaddition
title_full Discovery of 4-nitro-3-phenylisoxazole derivatives as potent antibacterial agents derived from the studies of [3 + 2] cycloaddition
title_fullStr Discovery of 4-nitro-3-phenylisoxazole derivatives as potent antibacterial agents derived from the studies of [3 + 2] cycloaddition
title_full_unstemmed Discovery of 4-nitro-3-phenylisoxazole derivatives as potent antibacterial agents derived from the studies of [3 + 2] cycloaddition
title_short Discovery of 4-nitro-3-phenylisoxazole derivatives as potent antibacterial agents derived from the studies of [3 + 2] cycloaddition
title_sort discovery of 4-nitro-3-phenylisoxazole derivatives as potent antibacterial agents derived from the studies of [3 + 2] cycloaddition
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455768/
https://www.ncbi.nlm.nih.gov/pubmed/36199305
http://dx.doi.org/10.1039/d2ra05009a
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