Design, Synthesis, Molecular Modeling and Anti-Hyperglycemic Evaluation of Quinazoline-Sulfonylurea Hybrids as Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) and Sulfonylurea Receptor (SUR) Agonists

New quinazoline-sulfonylurea hybrids were prepared and examined for their in vivo anti-hyperglycemic activities in STZ-induced hyperglycemic rats using glibenclamide as a reference drug. Compounds VI-6-a, V, IV-4, VI-4-c, IV-6, VI-2-a, IV-1, and IV-2 were more potent than the reference glibenclamide...

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Detalles Bibliográficos
Autores principales: El-Zahabi, Mohamed Ayman, Bamanie, Faida H., Ghareeb, Salah, Alshaeri, Heba K., Alasmari, Moudi M., Moustafa, Mohamed, Al-Marzooki, Zohair, Zayed, Mohamed F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455857/
https://www.ncbi.nlm.nih.gov/pubmed/36077003
http://dx.doi.org/10.3390/ijms23179605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455857/
https://www.ncbi.nlm.nih.gov/pubmed/36077003
http://dx.doi.org/10.3390/ijms23179605

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