Sphingosine-1-Phosphate (S1P) Lyase Inhibition Aggravates Atherosclerosis and Induces Plaque Rupture in ApoE(−/−)  Mice

Altered plasma sphingosine-1-phosphate (S1P) concentrations are associated with clinical manifestations of atherosclerosis. However, whether long-term elevation of endogenous S1P is pro- or anti-atherogenic remains unclear. Here, we addressed the impact of permanently high S1P levels on atherosclero...

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Detalles Bibliográficos
Autores principales: Keul, Petra, Peters, Susann, von Wnuck Lipinski, Karin, Schröder, Nathalie H., Nowak, Melissa K., Duse, Dragos A., Polzin, Amin, Weske, Sarah, Gräler, Markus H., Levkau, Bodo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455951/
https://www.ncbi.nlm.nih.gov/pubmed/36077004
http://dx.doi.org/10.3390/ijms23179606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455951/
https://www.ncbi.nlm.nih.gov/pubmed/36077004
http://dx.doi.org/10.3390/ijms23179606

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