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Sphingosine-1-Phosphate (S1P) Lyase Inhibition Aggravates Atherosclerosis and Induces Plaque Rupture in ApoE(−/−) Mice

Altered plasma sphingosine-1-phosphate (S1P) concentrations are associated with clinical manifestations of atherosclerosis. However, whether long-term elevation of endogenous S1P is pro- or anti-atherogenic remains unclear. Here, we addressed the impact of permanently high S1P levels on atherosclero...

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Detalles Bibliográficos
Autores principales:	Keul, Petra, Peters, Susann, von Wnuck Lipinski, Karin, Schröder, Nathalie H., Nowak, Melissa K., Duse, Dragos A., Polzin, Amin, Weske, Sarah, Gräler, Markus H., Levkau, Bodo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455951/ https://www.ncbi.nlm.nih.gov/pubmed/36077004 http://dx.doi.org/10.3390/ijms23179606

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