Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics

The design and development of analgesics with mixed-opioid receptor interactions has been reported to decrease side effects, minimizing respiratory depression and reinforcing properties to generate safer analgesic therapeutics. We synthesized bis-cyclic guanidine heterocyclic peptidomimetics from re...

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Detalles Bibliográficos
Autores principales: McLaughlin, Jay P., Rayala, Ramanjaneyulu, Bunnell, Ashley J., Tantak, Mukund P., Eans, Shainnel O., Nefzi, Khadija, Ganno, Michelle L., Dooley, Colette T., Nefzi, Adel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455983/
https://www.ncbi.nlm.nih.gov/pubmed/36077029
http://dx.doi.org/10.3390/ijms23179623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455983/
https://www.ncbi.nlm.nih.gov/pubmed/36077029
http://dx.doi.org/10.3390/ijms23179623

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