Enantiocontrolled Preparation of ϒ-Substituted Cyclohexenones: Synthesis and Kinase Activity Assays of Cyclopropyl-Fused Cyclohexane Nucleosides

The enantioselective preparation of the two isomers of 4-hydroxy-2-cyclohexanone derivatives 1a,b was achieved, starting from a common cyclohexenone, through asymmetric transfer hydrogenation (ATH) reactions using bifunctional ruthenium catalysts. From these versatile intermediates, a stereoselectiv...

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Detalles Bibliográficos
Autores principales: Jurado, Sergio, Domínguez-Pérez, Beatriz, Illa, Ona, Balzarini, Jan, Busqué, Félix, Alibés, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456008/
https://www.ncbi.nlm.nih.gov/pubmed/36077100
http://dx.doi.org/10.3390/ijms23179704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456008/
https://www.ncbi.nlm.nih.gov/pubmed/36077100
http://dx.doi.org/10.3390/ijms23179704

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