Ligand-Based Virtual Screening and Molecular Docking of Benzimidazoles as Potential Inhibitors of Triosephosphate Isomerase Identified New Trypanocidal Agents

Trypanosoma cruzi (T. cruzi) is a parasite that affects humans and other mammals. T. cruzi depends on glycolysis as a source of adenosine triphosphate (ATP) supply, and triosephosphate isomerase (TIM) plays a key role in this metabolic pathway. This enzyme is an attractive target for the design of n...

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Detalles Bibliográficos
Autores principales: Vázquez-Jiménez, Lenci K., Juárez-Saldivar, Alfredo, Gómez-Escobedo, Rogelio, Delgado-Maldonado, Timoteo, Méndez-Álvarez, Domingo, Palos, Isidro, Bandyopadhyay, Debasish, Gaona-Lopez, Carlos, Ortiz-Pérez, Eyra, Nogueda-Torres, Benjamín, Ramírez-Moreno, Esther, Rivera, Gildardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456061/
https://www.ncbi.nlm.nih.gov/pubmed/36077439
http://dx.doi.org/10.3390/ijms231710047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456061/
https://www.ncbi.nlm.nih.gov/pubmed/36077439
http://dx.doi.org/10.3390/ijms231710047

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