Cargando…

Reversal of High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Metformin Combined with PGG, an Inducer of Glycine N-Methyltransferase

Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidities and mortality, and no effective drug treatment currently exists. We aimed to develop a novel treatment strategy to induce the expression of glycine N-methyltransferase (GNMT), which is an important enzyme regulati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Ming-Hui, Li, Wei-You, Wu, Ching-Fen, Lee, Yi-Ching, Chen, Allan Yi-Nan, Tyan, Yu-Chang, Chen, Yi-Ming Arthur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456083/ https://www.ncbi.nlm.nih.gov/pubmed/36077467 http://dx.doi.org/10.3390/ijms231710072

Ejemplares similares

Genetic Polymorphisms of the Glycine N-Methyltransferase and Prostate Cancer Risk in the Health Professionals Follow-Up Study
por: Chen, Marcelo, et al.
Publicado: (2014)

MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma
por: Hung, Jung-Hsien, et al.
Publicado: (2018)

Loss of Glycine N-Methyltransferase Associates with Angiopoietin-Like Protein 8 Expression in High Fat-Diet-Fed Mice
por: Huang, Jian-Wei, et al.
Publicado: (2019)

Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver
por: Liao, Yi-Jen, et al.
Publicado: (2016)

Folic Acid Ameliorates Renal Injury in Experimental Obstructive Nephropathy: Role of Glycine N-Methyltransferase
por: Kuo, Ko-Lin, et al.
Publicado: (2023)

Androgen response element of the glycine N-methyltransferase gene is located in the coding region of its first exon
por: Lee, Cheng-Ming, et al.
Publicado: (2013)

The inhibitory effects of PGG and EGCG against the SARS-CoV-2 3C-like protease
por: Chiou, Wei-Chung, et al.
Publicado: (2022)

Synthesis, characterization, and in vivo efficacy evaluation of PGG–docetaxel conjugate for potential cancer chemotherapy
por: Yang, Danbo, et al.
Publicado: (2012)

PGG.Han: the Han Chinese genome database and analysis platform
por: Gao, Yang, et al.
Publicado: (2020)

N-3 polyunsaturated fatty acids decrease levels of doxorubicin-induced reactive oxygen species in cardiomyocytes -- involvement of uncoupling protein UCP2
por: Hsu, Hsiu-Ching, et al.
Publicado: (2014)

Reversal of Vascular Calcification and Aneurysms in a Rat Model Using Dual Targeted Therapy with EDTA- and PGG-Loaded Nanoparticles
por: Nosoudi, Nasim, et al.
Publicado: (2016)

Utilizing glycine N-methyltransferasegene knockout mice as a model for identification of missing proteins in hepatocellular carcinoma
por: Yang, Ming-Hui, et al.
Publicado: (2017)

Metformin treatment reverses high fat diet- induced non-alcoholic fatty liver diseases and dyslipidemia by stimulating multiple antioxidant and anti-inflammatory pathways
por: Yasmin, Tahmina, et al.
Publicado: (2021)

Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes
por: Chang, Ming-Min, et al.
Publicado: (2018)

Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor
por: Tan, Haozhou, et al.
Publicado: (2022)

Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor
por: Tan, Haozhou, et al.
Publicado: (2022)

High Capability of Pentagalloylglucose (PGG) in Inhibiting Multiple Types of Membrane Ionic Currents
por: Chang, Wei-Ting, et al.
Publicado: (2020)

PGG.MHC: toward understanding the diversity of major histocompatibility complexes in human populations
por: Zhao, Xiaohan, et al.
Publicado: (2022)

Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
por: Lee, Yi-Ru, et al.
Publicado: (2016)

Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation
por: Chan, Anissa S. H., et al.
Publicado: (2016)

PGG.Population: a database for understanding the genomic diversity and genetic ancestry of human populations
por: Zhang, Chao, et al.
Publicado: (2018)

Cloning and Functional Identification of Phosphoethanolamine Methyltransferase in Soybean (Glycine max)
por: Ji, Xiaomin, et al.
Publicado: (2021)

Metformin ameliorates maternal high-fat diet-induced maternal dysbiosis and fetal liver apoptosis
por: Huang, Szu-Wei, et al.
Publicado: (2021)

Ophiopogonin D ameliorates non‑alcoholic fatty liver disease in high‑fat diet‑induced obese mice by improving lipid metabolism, oxidative stress and inflammatory response
por: Huang, Xi, et al.
Publicado: (2023)

AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damage
por: Fang, Cheng-Chieh, et al.
Publicado: (2018)

Identification of 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma
por: Kant, Rajni, et al.
Publicado: (2016)

Effect of Metformin on a Preeclampsia-Like Mouse Model Induced by High-Fat Diet
por: Wang, Fuchuan, et al.
Publicado: (2019)

Glycine protects against high sucrose and high fat-induced non-alcoholic steatohepatitis in rats
por: Zhou, Xin, et al.
Publicado: (2016)

PGG.SNV: understanding the evolutionary and medical implications of human single nucleotide variations in diverse populations
por: Zhang, Chao, et al.
Publicado: (2019)

Aldehyde Dehydrogenase Mutation Exacerbated High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease with Gut Microbiota Remodeling in Male Mice
por: Yang, Sien-Sing, et al.
Publicado: (2021)

Convergent Mechanistic Features between the Structurally Diverse N- and O-Methyltransferases: Glycine N-Methyltransferase and Catechol O-Methyltransferase
por: Zhang, Jianyu, et al.
Publicado: (2016)

PGG.SV: a whole-genome-sequencing-based structural variant resource and data analysis platform
por: Wang, Yimin, et al.
Publicado: (2022)

Nuclear localization dictates hepatocarcinogenesis suppression by glycine N-methyltransferase
por: Simile, Maria M., et al.
Publicado: (2021)

Penta-o-galloyl-beta-d-Glucose (PGG) inhibits inflammation in human rheumatoid arthritis synovial fibroblasts and rat adjuvant-induced arthritis model
por: Umar, Sadiq, et al.
Publicado: (2022)

High Fat Diet with a High Monounsaturated Fatty Acid and Polyunsaturated/Saturated Fatty Acid Ratio Suppresses Body Fat Accumulation and Weight Gain in Obese Hamsters
por: Yang, Suh-Ching, et al.
Publicado: (2017)

Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer
por: Lin, Ruo-Kai, et al.
Publicado: (2014)

Mei-Gin Formula Ameliorates Obesity through Lipolysis, Fatty Oxidation, and Thermogenesis in High-Fat Diet-Induced Obese Rats
por: Cheng, Hsin-Lin, et al.
Publicado: (2023)

Imprime PGG Enhances Anti-Tumor Effects of Tumor-Targeting, Anti-Angiogenic, and Immune Checkpoint Inhibitor Antibodies
por: Chan, Anissa S. H., et al.
Publicado: (2022)

Beneficial effects of paeoniflorin on non-alcoholic fatty liver disease induced by high-fat diet in rats
por: Ma, Zhihong, et al.
Publicado: (2017)

Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells
por: Ottaviani, Silvia, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_009daojb0cuk3789lknkbp61hf