Crystal Structures of the Clostridium botulinum Neurotoxin A6 Cell Binding Domain Alone and in Complex with GD1a Reveal Significant Conformational Flexibility

Clostridium botulinum neurotoxin A (BoNT/A) targets the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, by cleaving synaptosomal-associated protein of 25 kDa size (SNAP-25). Cleavage of SNAP-25 results in flaccid paralysis due to repression of synaptic transmis...

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Detalles Bibliográficos
Autores principales: Gregory, Kyle S., Newell, Anna R., Mojanaga, Otsile O., Liu, Sai Man, Acharya, K. Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456117/
https://www.ncbi.nlm.nih.gov/pubmed/36077016
http://dx.doi.org/10.3390/ijms23179620

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456117/
https://www.ncbi.nlm.nih.gov/pubmed/36077016
http://dx.doi.org/10.3390/ijms23179620

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