Binding Thermodynamics and Dissociation Kinetics Analysis Uncover the Key Structural Motifs of Phenoxyphenol Derivatives as the Direct InhA Inhibitors and the Hotspot Residues of InhA

Given the current epidemic of multidrug-resistant tuberculosis, there is an urgent need to develop new drugs to combat drug-resistant tuberculosis. Direct inhibitors of the InhA target do not require activation and thus can overcome drug resistance caused by mutations in drug-activating enzymes. In...

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Detalles Bibliográficos
Autores principales: Zhang, Qianqian, Han, Jianting, Zhu, Yongchang, Tan, Shuoyan, Liu, Huanxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456180/
https://www.ncbi.nlm.nih.gov/pubmed/36077494
http://dx.doi.org/10.3390/ijms231710102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456180/
https://www.ncbi.nlm.nih.gov/pubmed/36077494
http://dx.doi.org/10.3390/ijms231710102

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