LAG-3 as a Potent Target for Novel Anticancer Therapies of a Wide Range of Tumors

LAG-3 (Lymphocyte activation gene 3) protein is a checkpoint receptor that interacts with LSEC-tin, Galectin-3 and FGL1. This interaction leads to reduced production of IL-2 and IFN-γ. LAG-3 is widely expressed in different tumor types and modulates the tumor microenvironment through immunosuppressi...

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Detalles Bibliográficos
Autores principales: Sauer, Natalia, Szlasa, Wojciech, Jonderko, Laura, Oślizło, Małgorzata, Kunachowicz, Dominika, Kulbacka, Julita, Karłowicz-Bodalska, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456311/
https://www.ncbi.nlm.nih.gov/pubmed/36077354
http://dx.doi.org/10.3390/ijms23179958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456311/
https://www.ncbi.nlm.nih.gov/pubmed/36077354
http://dx.doi.org/10.3390/ijms23179958

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