Cargando…
The Distinct Roles of LKB1 and AMPK in p53-Dependent Apoptosis Induced by Cisplatin
Liver kinase B1 (LKB1) is a serine/threonine protein kinase that acts as a key tumor suppressor protein by activating its downstream kinases, such as AMP-activated protein kinase (AMPK). However, the regulatory actions of LKB1 and AMPK on DNA damage response (DDR) remain to be explored. In this stud...
Autores principales: | Shimada, Tatsuya, Yabuki, Yohsuke, Noguchi, Takuya, Tsuchida, Mei, Komatsu, Ryuto, Hamano, Shuhei, Yamada, Mayuka, Ezaki, Yusuke, Hirata, Yusuke, Matsuzawa, Atsushi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456506/ https://www.ncbi.nlm.nih.gov/pubmed/36077459 http://dx.doi.org/10.3390/ijms231710064 |
Ejemplares similares
-
Reactive sulfur species disaggregate the SQSTM1/p62-based aggresome-like induced structures via the HSP70 induction and prevent parthanatos
por: Yamada, Yutaro, et al.
Publicado: (2023) -
The E3 Ubiquitin-Protein Ligase RNF4 Promotes TNF-α-Induced Cell Death Triggered by RIPK1
por: Shimada, Tatsuya, et al.
Publicado: (2021) -
trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway
por: Hirata, Yusuke, et al.
Publicado: (2021) -
TAK1 Mediates ROS Generation Triggered by the Specific Cephalosporins through Noncanonical Mechanisms
por: Suzuki, Midori, et al.
Publicado: (2020) -
Brefeldin A-Inhibited Guanine Nucleotide-Exchange Factor 1 (BIG1) Governs the Recruitment of Tumor Necrosis Factor Receptor-Associated Factor 2 (TRAF2) to Tumor Necrosis Factor Receptor 1 (TNFR1) Signaling Complexes
por: Noguchi, Takuya, et al.
Publicado: (2016)