Transgenic Overexpression of Myocilin Leads to Variable Ocular Anterior Segment and Retinal Alterations Associated with Extracellular Matrix Abnormalities in Adult Zebrafish

Myocilin is an enigmatic glaucoma-associated glycoprotein whose biological role remains incompletely understood. To gain novel insight into its normal function, we used transposon-mediated transgenesis to generate the first zebrafish line stably overexpressing myocilin [Tg(actb1:myoc-2A-mCherry)]. q...

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Detalles Bibliográficos
Autores principales: Atienzar-Aroca, Raquel, Ferre-Fernández, Jesús-José, Tevar, Angel, Bonet-Fernández, Juan-Manuel, Cabañero, María-José, Ruiz-Pastor, María-José, Cuenca, Nicolás, Aroca-Aguilar, José-Daniel, Escribano, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456529/
https://www.ncbi.nlm.nih.gov/pubmed/36077382
http://dx.doi.org/10.3390/ijms23179989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456529/
https://www.ncbi.nlm.nih.gov/pubmed/36077382
http://dx.doi.org/10.3390/ijms23179989

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