Brain endothelial STING1 activation by Plasmodium-sequestered heme promotes cerebral malaria via type I IFN response

Cerebral malaria (CM) is a life-threatening form of Plasmodium falciparum infection caused by brain inflammation. Brain endothelium dysfunction is a hallmark of CM pathology, which is also associated with the activation of the type I interferon (IFN) inflammatory pathway. The molecular triggers and...

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Detalles Bibliográficos
Autores principales: Pais, Teresa F., Ali, Hajrabibi, Moreira da Silva, Joana, Duarte, Nádia, Neres, Rita, Chhatbar, Chintan, Acúrcio, Rita C., Guedes, Rita C., Strano Moraes, Maria Carolina, Costa-Silva, Bruno, Kalinke, Ulrich, Penha-Gonçalves, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457060/
https://www.ncbi.nlm.nih.gov/pubmed/36037380
http://dx.doi.org/10.1073/pnas.2206327119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457060/
https://www.ncbi.nlm.nih.gov/pubmed/36037380
http://dx.doi.org/10.1073/pnas.2206327119

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