Amelioration of pathologic α-synuclein-induced Parkinson’s disease by irisin

Physical activity provides clinical benefit in Parkinson’s disease (PD). Irisin is an exercise-induced polypeptide secreted by skeletal muscle that crosses the blood–brain barrier and mediates certain effects of exercise. Here, we show that irisin prevents pathologic α-synuclein (α-syn)-induced neur...

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Detalles Bibliográficos
Autores principales: Kam, Tae-In, Park, Hyejin, Chou, Shih-Ching, Van Vranken, Jonathan G., Mittenbühler, Melanie J., Kim, Hyeonwoo, A, Mu, Choi, Yu Ree, Biswas, Devanik, Wang, Justin, Shin, Yu, Loder, Alexis, Karuppagounder, Senthilkumar S., Wrann, Christiane D., Dawson, Valina L., Spiegelman, Bruce M., Dawson, Ted M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457183/
https://www.ncbi.nlm.nih.gov/pubmed/36044549
http://dx.doi.org/10.1073/pnas.2204835119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457183/
https://www.ncbi.nlm.nih.gov/pubmed/36044549
http://dx.doi.org/10.1073/pnas.2204835119

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