Thiomorpholino oligonucleotides as a robust class of next generation platforms for alternate mRNA splicing

Recent advances in drug development have seen numerous successful clinical translations using synthetic antisense oligonucleotides (ASOs). However, major obstacles, such as challenging large-scale production, toxicity, localization of oligonucleotides in specific cellular compartments or tissues, an...

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Detalles Bibliográficos
Autores principales: Le, Bao T., Paul, Sibasish, Jastrzebska, Katarzyna, Langer, Heera, Caruthers, Marvin H., Veedu, Rakesh N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457326/
https://www.ncbi.nlm.nih.gov/pubmed/36037350
http://dx.doi.org/10.1073/pnas.2207956119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457326/
https://www.ncbi.nlm.nih.gov/pubmed/36037350
http://dx.doi.org/10.1073/pnas.2207956119

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