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Thiomorpholino oligonucleotides as a robust class of next generation platforms for alternate mRNA splicing
Recent advances in drug development have seen numerous successful clinical translations using synthetic antisense oligonucleotides (ASOs). However, major obstacles, such as challenging large-scale production, toxicity, localization of oligonucleotides in specific cellular compartments or tissues, an...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457326/ https://www.ncbi.nlm.nih.gov/pubmed/36037350 http://dx.doi.org/10.1073/pnas.2207956119 |