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Mapping the per-residue surface electrostatic potential of CAPRIN1 along its phase-separation trajectory

Electrostatic interactions and charge balance are important for the formation of biomolecular condensates involving proteins and nucleic acids. However, a detailed, atomistic picture of the charge distribution around proteins during the phase-separation process is lacking. Here, we use solution NMR...

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Detalles Bibliográficos
Autores principales: Toyama, Yuki, Rangadurai, Atul Kaushik, Forman-Kay, Julie D., Kay, Lewis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457416/
https://www.ncbi.nlm.nih.gov/pubmed/36040869
http://dx.doi.org/10.1073/pnas.2210492119